This was an interesting video. I remembered the anecdote of Steve Jobs talking to then-Pepsi CEO John Sculley, when attempting to convince him to join Apple: "Do you want to spend the rest of your life selling sugared water or do you want a chance to change the world?"
I've made this lament before to my wife, who works in health care: She makes a difference in people's lives, and I don't. I enjoy my work, most of the time, and I make a good living at it, but sometimes it feels so inconsequential and insignificant. Misemployment is a difficult problem.